There is a growing trend towards the use of CBD cream for arthritis and other forms of pain. Proponents of the cannabinoid say they rub the topical into their skin and experience relief. CDC data reports that approximately 63 million Americans have arthritis, as diagnosed by a doctor. It projects a figure of 78 million by 2040 and around 70 million Americans have chronic pain.

The most common treatments for pain are opioid painkillers and OTC drugs. But they only offer a reprieve. Over time, they become less effective, and you need a higher dose to achieve the same effect as before. Eventually, patients become addicted. Well over 100 people die each day from an opioid overdose in the United States. It is hardly a surprise that CBD cream for pain is becoming a viable alternative.

CBD pain cream, also known as a topical, is a product that you rub into your skin in the painful area. In theory, it interacts with your body’s endocannabinoid system (ECS) and helps ease the pain. We will check out five of the best CBD cream for arthritis brands in this article. First, let’s look into the science behind why CBD could help you.

What Are CBD Creams & Topicals?

You can find topical products in the shape of creams, salves, and lotions. Ultimately, all of these CBD pain relief cream options perform the same function. Use a small amount of the ointment and apply it anywhere that hurts. Common areas for application include the neck & shoulders, soles of the feet, elbow, knees & other joints. You can also use a CBD pain relief rub.

Proponents of CBD topical cream say that it helps reduce inflammation and the feeling of pain. Remember, the body produces natural endocannabinoids. The theory is that a lack of endocannabinoid production causes the symptoms of many medical conditions. If you add CBD to the mix, it could help restore your body to a state of balance (homeostasis).

Another suggestion is that CBD ‘kick starts’ your body’s production of endocannabinoids. The result is a reduction in inflammation and a soothing sensation. Either way, it is seemingly the interaction with the ECS’ CB receptors that is the reason for any positive effects. Also, there is an inherent link between inflammation and pain. Reduce the former, and you can feel the benefits of less of the latter.

CBD Pain Cream for Arthritis and Joint Pain – Why is it Potentially Effective?

Cannabidiol is a non-intoxicating compound found in marijuana and hemp. It may help combat a variety of symptoms. Its apparent benefits relate to its interaction with our body’s natural ECS. Within our ECS lie cannabinoid receptors. CB1 and CB2 are the best known to date, but researchers believe there are others. There is a possibility that using CBD arthritis cream can help manage symptoms.

Research so far suggests that the receptors are like a ‘lock,’ and cannabinoids are the ‘key.’ You find CB1 receptors primarily in the brain and nervous system. The benefits of unlocking these receptors may include reduced anxiety and depression. You find CB2 receptors in immune cells. Alterations to CB2 receptors impact cardiovascular, psychiatric, and gastrointestinal diseases.

THC is an intoxicating cannabinoid, and it strongly binds with CB1 and CB2 receptors. CBD, on the other hand, has no such binding affinity. So, how can CBD cream for joint pain work? Researchers believe that cannabidiol’s effects are down to indirect actions. For example, CBD activates TRPV1 receptors. These receptors are involved in regulating inflammation, body temperature, and pain.

CBD also inhibits Fatty Acid Amide Hydrolase (FAAH). The result is the creation of higher endocannabinoid levels. A prime example is a boost in the release of anandamide, the ‘bliss molecule.’ As the nickname suggests, anandamide plays a significant role in the generation of pleasure.

What Does the Research Say?

Vuckovic et al. published a study in Frontiers in Pharmacology in November 2018. It reviewed dozens of studies from 1975 which looked at whether cannabinoids could help with pain. In the review, the researchers pointed out that cannabinoids acted via CB receptors. It also said that cannabinoids inhibit the release of neuropeptides and neurotransmitters from presynaptic nerve endings.

The review stated that there is “a moderate amount of evidence that cannabis/cannabinoids exhibit analgesic activity.” The primary reason why data is limited is due to the prohibition of hemp. Overall, the researchers concluded that CBD was effective in pain management of neuropathic pain and fibromyalgia. Moreover, it doesn’t cause serious side effects.

Philpott et al. had a study published in the Pain journal in December 2017. It looked at CBD’s effects on pain and inflammation in mice. The researchers induced osteoarthritis (OA) in male Wistar rats. Overall, the team found that the local administration of cannabidiol blocked OA pain. The researchers concluded that the compound is potentially a safe and therapeutic method of treating OA pain. But whether it would have the same effect on humans is still based in theory.

Waiting Time & Bioavailability

When you purchase CBD cream for arthritis, apply it directly to the skin and wait for it to absorb. The process involves the cannabidiol in the salve interacting with localized cannabinoid receptors. CBD topicals are far superior to their THC counterpart because CBD’s permeability is ten times higher. Most users report feeling a ‘difference’ after approximately 10-15 minutes. However, it varies depending on a myriad of factors.

The bioavailability of CBD topicals is not as well-studied as other methods of consumption. For instance, we know that the likely absorption rate of vaporized cannabinoids is between 34% and 56%. There isn’t the same level of data surrounding creams. The average bioavailability of rectally applied CBD products is around 13.5%. This figure is apparently up to 50% higher than oral administration.

Various researchers have discovered that CBD cream for pain is often useful in providing relief. Ultimately, that is all one cares about when selecting a CBD cream for arthritis.

CBD Pain Cream – Pros & Cons


  • It has the potential to provide localized relief.
  • Many users claim it works rapidly.
  • Depending on the extra ingredients, CBD cream for pain is also good for the skin.
  • It is a useful alternative to CBD oil or vaporized products.
  • It is quick and easy to apply.


  • The cannabinoid content is often not particularly high.
  • CBD pain cream may not have a high bioavailability rate.
  • It is often messy to apply, with greasy residue left on the hands.
  • Some brands are costly.
  • It is part of an unregulated industry.

How we have explained CBD pain cream a little better, let’s review five of the top brands.

Best CBD Cream for Pain

1 – PureKana

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PureKana has a reputation as one of the world’s top CBD brands. It is based in Scottsdale, Arizona, and aims to provide high-quality hemp products at a reasonable price. All of its hemp is free from solvents, fertilizers, pesticides, and herbicides. PureKana’s CBD is also GMO-free, with every batch of products tested by a third-party lab.

Review of PureKana CBD Cream for Pain

The PureKana CBD topical cream range consists of three products. The classic topical CBD ointment comes in a 3.4-ounce jar and contains 600mg of CBD for $80. Customers say it is smooth and silky. It even has the benefit of moisturizing the skin!

The menthol roll-on gel is also $80 for 600mg of CBD. Once again, use it by rubbing a thin film of it on the skin. PureKana recommends not using this CBD cream for pain more than four times a day.

The Transdermal patch is the last of the range. It is waterproof, and you use it by sticking it on the affected area. According to the brand, each 60mg CBD patch lasts for up to four days! You can purchase one piece for $17.99 or a 3-pack for $48.99.

2 – Green Roads

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The Green Roads CBD brand has won numerous awards since its formation. Unlike other companies that tell you little about themselves, Green Roads is more forthright. Arby Barroso and Laura Baldwin Fuentes are the co-founders. The brand boasts that it is sold in over 10,000 locations! It was also rated the #1 privately-held CBD company in the United States.

Review of Green Roads CBD Pain Cream

You have the choice of soothing CBD skin relief cream or something with a little more edge. The soothing cream includes bentonite clay, lavender, and chamomile for a relaxing sensation. 150mg of CBD costs $34.95, while 300mg costs $62.50.

The Muscle & Joint heat relief option is a roll-on with a little extra ‘spice.’ It includes menthol and natural pepper extracts. It isn’t quite as tranquil as the soothing cream, but users say it gets the job done. 250mg costs $48.95 and 500mg costs $70.50. There is also a CBD skin relief cream. It costs $39.99 and contains 200mg of CBD.

3 – Premium Jane

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Like PureKana, Premium Jane has its HQ in Scottsdale, Arizona. It is an organization at the forefront of the industry. Its team consists of agricultural experts, biologists, chemists, and marketing developers. The content of all PJ products is lab-verified. The brand also has a positive reputation for the standard of its customer service.

Review of Premium Jane CBD Cream for Pain

The company doesn’t explicitly state that it sells CBD topical cream for arthritis. However, many customers tend to use Premium Jane’s topical salve for this reason. You can purchase a 750mg CBD tub for $75 or a 1,500mg tub for $125. The smaller option provides you with the soothing effect of eucalyptus. The larger version offers a cocoa butter scent.

Here is a quick overview of the rest of Premium Jane’s topicals range:

  • CBD After Sun Spray: 300mg for $45.
  • CBD Creamy Charcoal Facial Cleanser: 200mg for $40. There is also a CBD Oil Control Facial Cleanser for the same price.
  • CBD Facial Day Cream: 300mg for $43.
  • Facial Night Cream: 300mg for $45.
  • CBD Facial Scrub: 200mg for $40.
  • CBD Rejuvenation Cream: 200mg for $40.

4 – Hemp Bombs

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A combination of savvy marketing and a variety of products has helped Hemp Bombs reach the top of the CBD ladder. It has achieved all this without giving away much information about its formation or founders! The brand’s unique packaging is eye-catching and has gone a long way towards making it such a recognizable company.

Review of Hemp Bombs CBD Pain Cream

While other companies are cautious about their CBD topicals, Hemp Bombs is not! It leaves you in no doubt as to the purpose of the cream. For a start, it calls it ‘CBD Pain Freeze.’ Not a lot is left open to interpretation! The 1oz tub contains 50mg of CBD for $14.99. The 4oz container has 200mg of CBD for $39.99.

Hemp Bombs recommends using it no more than four times a day. One of its active ingredients is menthol, so get ready for a soothing ‘burning’ sensation! The brand says its product is useful if you have a sunburn, muscle aches, or post-workout pain. However, it is primarily CBD cream for joint pain.

5 – CBD Essence

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This is yet another brand that enables you to use CBD cream for arthritis. Don Balou founded the company in 2014. He has lifelong experience in nutrition, health and wellness, and health food research. Suzie Salah is the president, and Robert Emma is the managing partner. The brand researches and produces its CBD products, with full third-party lab reports.

Review of CBD Essence’s CBD Lotion

The brand offers two main products. Its CBD All-Purpose Lotion contains 600mg of CBD for just $51. It is one of the best-value topicals on the market. It combines cannabidiol with eucalyptus for a soothing feeling.

The CBD Sport Hot Muscle Rub is at the other end of the spectrum. It is also $51 for 600mg of CBD in a 2oz tub. The other ingredient, aside from CBD, is capsaicin. This lotion provides a warm, almost ‘stinging’ sensation. It takes a while to get used to it, but when you do, it will feel pleasant.

Best CBD Cream for Pain: Final Thoughts

At present, there is no ‘cure’ for arthritis. The next best thing is to find a way to alleviate symptoms such as joint pain. The list above names five worthy brands that sell high-quality products. None of them sell CBD cream for arthritis specifically. However, countless users of CBD salves and creams claim that it provides them with tremendous relief.

If you decide to use CBD pain cream, make sure you apply it liberally to the affected area. The bioavailability is not high, but you may find that it ‘works’ relatively quickly. Of course, everyone is different. What helps one person may not have any impact on another. Bear that in mind when seeking CBD cream for pain.